Monday , 24 April 2017

Solubility and Dissolution Rate Enhancement of Olmesartan Medoxomil by Hydrotropy and Development of Oral Disintegrating Tablets

Angilicam Avinash*, Avula Sushma, Koneti Lalasa, Siddabathina Prasanth Kumar, Thumati Gowthami, Dr. M. Sreenivasulu  
Narayana Pharmacy College, Chinthareddypalem, Nellore, Andhra Pradesh, India-524003.

A B S T R A C T
This research work was designed to enrich the solubility of olmesartan medoxomil by Hydrotropy technique and to develop the oral disintegrating tablets. Olmesartan medoxomil is an anti-hypertensive drug which belongs to BCS Class II having low solubility and therefore low oral bioavailability (26%). In the present study, HMs of olmesartan medoxomil with water soluble carriers like sodium acetate, sodium benzoate and urea were prepared by solvent evaporation method in different weight ratios and the optimized Hydrotropic mixture (HM) was used in the development of  olmesartan medoxomil oral disintegrating tablets. HMs was evaluated for drug content and in vitro dissolution studies. The results revealed that the dissolution of olmesartan medoxomil HMs was improved greatly for F6 when compared with that of remaining formulations which shows 99.38% of drug release within 60 minutes.  The above optimized HM  was formulated as oral disintegrating tablets by direct compression using superdisintegrants like Croscarmellose sodium (CCS), (ODT1-ODT3), and sodium starch glycolate (SSG), (ODT4-ODT6). Olmesartan medoxomil oral disintegrating tablets were evaluated for pre-compression and post compression parameters. Amongst the formulations prepared (ODT1-ODT6), ODT6 was found to be effective formulation comprising of SSG which showed the drug release of 96.31% within 12 min.
Keywords: Bioavailability, croscarmellose sodium, Hydrotropy, Olmesartan medoxomil, Oral disintegrating tablets, Sodium starch glycolate, Solubility.  

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