Tuesday , 20 March 2018

Sodium Tetrachloroaurate (III) dihydrate : A simple and Efficient Catalyst for the Synthesis of 1,4-dihydropyridine (Hantzsch Pyridines)

K. Pavan Kumar, Dr. B. Sammaiah, M. Venkanna, R. Madhusudhan Raju*
Department of Chemistry, Osmania University, Hyderabad-07.

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1,4-Dihydropyridine  synthesis  has  been  carried  out  using Sodium Tetrachloroaurate (III) dihydrate , as a catalyst. This  protocol  is  applicable  to  a  variety  of  aldehydes with β-ketoester  and  ammonium  acetate  to  afford  the  corresponding  Hantzsch pyridines  in  excellent  yields. This multicomponent condensation took placevery smoothly in acetonitrile reflux.

Keywords: Aldehydes, Di ketones, NH4OAc, Sodium Tetrachloroaurate (III) dihydrate, 1,4-dihydropyridine

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