K. Pavan Kumar, Dr. B. Sammaiah, M. Venkanna, R. Madhusudhan Raju*
Department of Chemistry, Osmania University, Hyderabad-07.
A B S T R A C T
1,4-Dihydropyridine synthesis has been carried out using Sodium Tetrachloroaurate (III) dihydrate , as a catalyst. This protocol is applicable to a variety of aldehydes with β-ketoester and ammonium acetate to afford the corresponding Hantzsch pyridines in excellent yields. This multicomponent condensation took placevery smoothly in acetonitrile reflux.
Keywords: Aldehydes, Di ketones, NH4OAc, Sodium Tetrachloroaurate (III) dihydrate, 1,4-dihydropyridine