Saturday , 16 December 2017

Simple Validated UV method for Tenofovirin Bulk and It’s Tablets Dosage Form

Kumar G, Ishaq B, Hindustan Abdul Ahad*, Haritha K, Mahadevi U, Aruna Bai M, Madhavi T
Balaji College of Pharmacy, Rudrampeta bypass, Ananthapuramu, Andhra Pradesh, India

A B S T R A C T
Tenofovir is prescribed to HIV patients. The present research work is to develop and validate Tenofovir by UV spectrometric method. Simple, accurate, precise and cost efficient spectrophotometric method has been developed for the estimation of Tenofovir in bulk and its tablets dosage form. The optimum condition for the analysis of the drug was established. The maximum wavelength (λmax) was found to be 260nm in water. The mean percentage recovery of Tenofovir was found to be in range of 99.40-101.64%. Beers law was obeyed in the concentration range of 10-200μg/ml.  Calibration curve shows a linear relationship between the absorbance and concentration. The line equation y = 0.026X+0.252 with R² = 0.998 was obtained. Validation was performed as ICH guidelines for linearity, accuracy, precision, LOD & LOQ. The proposed method may be suitable for analysis of Tenofovir in bulk and tablets formulation for routine quality control purposes.
Keywords: Tenofovir tablets, UV spectrophotometric, beers law

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