Similarity of Structure and Analgesic-Anti-Inflammatory Activity of the Novel Isatin Analogue

About author
R.A Hajare*, P.P. Chinchole
Principal, Shri BSPM’S B.Pharmacy College, Ambajogai, Dist Beed, Maharastra, India
E-mail: [email protected]

Abstract
Isatin (1H-indole-2,3-dione ) and its derivative demonstrate a diverse array of biological activities. Isatin and its 5-halo derivatives were reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C,C-N, C=N bonds. From the spectral studies, isatin were undergoes reaction at C-3 and N-1 position. N-benzyl 3-[(phenylimino)-hydrazono]-1,3-dihydro-indole-2-one,  Nbenzyl3-[(2,4-dinitrophenylimino)  -hydrazono]-1, 3-dihydro-indole-2-one, 3-[(phenylimino)-hydrazono]-1,3-dihydro-indole-2-one , 3-[(2,4-dinitro phenylimino)-hydrazono]-1,3-dihydro-indole-2-one, N-benzyl 3-[(phenylimino) hydrazono]-5-Chloro-1,3-dihydro-indole-2-one,3-[(phenylimino)-hydrazono]   5-chloro-1,3-dihydro-indole-2-one, 3-[(2,4-dinitro phenylimino)-hydrazono]-5-Chloro-1,3-dihydroindole-2-one,3-[(phenylimino)-hydrazono]-5Fluro-1,3-dihydro-indole-2-one,3-[(2,4-dinitrophenylimino)-hydrazono]5-fluro-1,3-dihydro-indole-2one,3-[(phenylimino)-hydrazono]-5Nitro-1,3-dihydro-indole-2-one,3-[(2,4-dinitro-phenylimino)-hydrazono]-5 Nitro-1,3-dihydro-indole-2-one  have been synthesized in present study and  discuss the similarity of structure and analgesic-anti-inflammatory activity.
Key words: Schiff’s base, n-benzylation, dimethylformamide, anti-inflammatory, analgesic.
Introduction
Isatin is a versatile compound isolated in 1988 and reported to possess a wide range of biological activity in mammals. Isatin also is a synthetically versatile substrate that can be used to prepare a large variety of heterocyclic compounds, such as indoles and quinolines, and as a raw material for drug synthesis. Schiff bases and mannich bases of isatin are known to possess a wide range of pharmacological properties including anticonvulsant, antibacterial, antiprotozoal, antifungal, antiviral, anti-HIV, tuberculostatic, analgesic, anticancer activities. In the view of this fact, we have planned the synthesis of some novel isatin analogue and screening them for analgesic-anti-inflammatory activity.