Tuesday , 24 October 2017

Samarium triflet: Sm(OTf)3 a simple and efficient catalyst for the synthesis of 1,4-dihydropyridine (Hantzsch pyridines)

M. Venkanna, Dr. B. Sammaiah, K. Srinuvasulu, Prof. R. Madhusudhan Raju*
Department of Chemistry, Osmania University, Hyderabad-07, Telangana

A B S T R A C T
1,4-Dihydropyridine  synthesis  has  been  carried  out  using  Samarium  triflet, as a catalyst. This  protocol  is  applicable  to  a variety  of  aldehydes with β-ketoester  and  ammonium  acetate  to  afford  the  corresponding  Hantzsch pyridines  in  excellent  yields. This multi component condensation took placevery smoothly in acetonitrile reflux.
Keywords: Aldehydes, Di ketones, NH4OAc, Samarium triflet, (Sm (OTf)3),1,4-dihydropyridine

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