Review: Synthesis and Applications of Schiff Bases

Mustapha C. Mandewale*¹, Bapu Thorat¹_, Udaysinha Patil¹ and Ramesh Yamgar^2
1Department of Chemistry, Government of Maharashtra’s, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari East Mumbai-400 060, India.
²Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon (W), Mumbai-400 062, India.

A B S T R A C T
Schiff bases are obtained by condensation of aldehyde with primary amine. It is also called as imine.  Since first synthesis of imine, number of methods has been discovered to enhance reaction yield, decrease reaction time as well as reduce hazardous reagents and reaction conditions. Compound with Schiff base core are widely used for industrial purposes and also exhibit a broad range of biological activities. An overview of synthetic methodologies used for the construction of Schiff base is also described.
Keywords: Schiff base, synthetic methodology, biological applications.