G. Venkata Lokesh, M.N. Bharath Kumar, M.B. Tamil Arasu, *K. Surendra
Rao’s College of Pharmacy, Chemudugunta, Venkatachalam, Nellore, Andhra Pradesh-524320
Central nervous system is one of the most sensitive environment in human body. It was protected by blood brain barrier, it maintains homeostasis by regulating the transport of chemicals at the brain interface. BBB is highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted number molecules from the blood to the brain, protecting it from injuries and diseases. However, this protection mechanism is also a major obstacle during disease state since it dramatically hinders the drug delivery. In recent years, various tactics have been applied to assist drugs to cross the BBB including osmotic disruption of the BBB and chemical modification of prodrugs. Nanoparticle mediated drug delivery is one of the advance and effective system to treat CNS disorders. The present review describes that structure and functions of BBB. And also focused on preparation methods and evaluation methods for nanoparticles, emerging methods for the nanoparticle drug delivery in blood brain barrier (BBB).
Keywords: Blood brain barrier (BBB), Nanoparticles Central nervous system, Brain, Prodrugs.