Navneet Kumar Verma*, Asha Roshan
Department of Pharmacy, Rameshwaram Institute of Technology and Management Lucknow (U.P), India
Faculty of Pharmacy, Varanasi College of Pharmacy, Varanasi, (U.P.), India
*e-mail : [email protected]
Nails drug delivery system (NDDS) is an important delivery system in mammals, in which their nails are highly affected by the fungal diseases. This review is to explore the difficulties in penetration of drug across nail plate & enhancement of bioavailability of antifungal drug. NDDS is the current topical treatments against the fungal infections by topical antifungal product lies in ineffectively overcoming the nail barrier. The clinical evidence suggests that a key to successful treatment of fungal diseases. The absorption of drugs into the nail unit, following topical application to the nail plate, is highly desirable to treat nail disorders, such as onychomycosis (fungal infections of the nail). Nail permeability is however quite low and limits topical therapy to early/mild disease states. The factors, which affect drug uptake and permeation through the nail plate such as solute molecular size, hydrophilicity / hydrophobicity, charge, and the nature of the vehicle, are then discussed, followed by ways of enhancing drug transport into and through the nail plate. . Finally, drug-containing nail lacquers which, like cosmetic varnish, are brushed onto the nail plates to form a film and from which drug is released and penetrates into the nail, recent advances and marketed products are reviewed.
Key words: NDDS, Nail plate, Fungal disease, Antifungal drugs, Nail barrier Etc.