Gajulapalle Sireesha*, Dommaraju Likhitha, Sadhana Priya, Kothapatnam Sai Pranavi
Pharm.D, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore
A B S T R A C T
It is a chronic inflammatory disorder of skin in which the epidermal cells are damaged by antibodies in the system. it is also called as auto immune disorder of joints. the newer formation of epidermal cells it takes 3-4 weeks but in psoriasis condition 3-4 days the faster development of epidermal cells are takes place. The causative factors are genetics HLA cw 6, alcohol, smoking, stress, life style factors, drugs. The diagnosis of disease includes skin biopsy-rays of joints. The symptoms include joint pain, joint infection, vasculitis, tendinitis, formation of red itchy plaques in the skin surface. The hyper activation of T-cells responsible for progression of disease. It forms the antigen processing complex responsible for the development of infection. The inflammatory cells, vascular changes are responsible for development of disease. The management of disease includes emollients, moistures, coal tar derivatives, anti TNF agents will reduce the progression of the disease.
Keywords: inflammation, emollients, infection, genetics.