Shaik Salma Sultana*, P. Sukumari
Jagan’s College of Pharmacy, Jangala kandriga, SPSR Nellore, Andhra Pradesh, India
Chaperones (stress proteins) are essential proteins to help the formation and maintenance of the proper conformation of other proteins and to promote cell survival after a large variety of environmental stresses. Therefore, normal chaperone function is a key factor for endogenous stress adaptation of several tissues. Development of membrane-interacting drugs to modify specific membrane domains, thereby modulating heat shock response, may be of considerable therapeutic benefit as well. In this review, we give an overview of the therapeutic approaches and list some of the key questions of drug development in this novel and promising therapeutic approach.
Keywords: Chaperone coinducers, chaperones, Hsp90, Hsp70, heat shock proteins, geldanamycin, stress proteins