Preparation and Characterization of Extended Release Matrix Tablets of Bisoprolol Fumerate Using Natural and Synthetic Polymers

Dr. Hareesh Dara*, Meesa Rajendar, D Siva Dinesh
St John College of Pharmcy, Hasanparthy, Hanamkonda, Telangana.

A B S T R A C T
The aim of the present study was to develop Extended release formulation of Bisoprolol to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K15M, Ethyl cellulose, Carbopol, Manugel were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e., 98.26% in 12 hours. It contains the HPMC K15M and Ethyl Cellulose combination polymer. It followed kars mayer peppas kinetics mechanism.
Keywords: Bisoprolol, HPMCK15M, Ethyl Cellulose, Carbopol 934, Manugel