T. Satyanarayana*, MA. Zeeshan Ahmed, Shaji George
Department of pharmaceutics, Browns College of pharmacy, Khammam, AP, India.
A B S T R A C T
The present study deals with the preparation characterization and evaluation of losartan (angiotensin II receptor antagonist for hypertension) nanoparticles. It may also delay progression of diabetic nephropathy, and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes, hypertension and micro-albuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours). The main objective of this present study is to design and evaluate the controlled release of nanoparticles of Losartan with a goal to increase the bioavailability, reduce dosing frequency, to improve patient compliance. Losartan nanoparticles emulsion were developed by using ultra-sonication method using chitosan as a polymer, Tween 80 as a surfactant and liquid paraffin and castor oil as an oily phase in different formulations. All formulations were evaluated for drug loading efficiency and in-vitro drug release studies. The optimized formulation F7 has been subjected for the evaluation of surface morphology (SEM), particle size (Zeta sizer). FTIR studies are done to know the interaction of drug and polymer. FTIR studies showed no evidence on interaction between drug and polymers.
Keywords: Nanoparticles, Chitosan, Losartan, Ultrasonication method.