Preparation and Evaluation of Urea Co-Inclusion Complexes of COQ10 for the Simultaneous Enhancement of Dissolution Profile and Its Stability

Vinod^1*, Vikaas Budhwaar², Arun Nanda^3
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
²Assistant Professor, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
³Professor, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

A B S T R A C T
Coenzyme Q10 is known as ubiquinone, ubiquinol, and ubidecarenone, an endogenous essential molecule present in every cell in the body. It is a fat-soluble, vitamin-like benzoquinone compound and has an essential role in the production of cellular energy in the form of ATP. However it has poor aqueous solubility and also suffers from photo instability.  In the present study, urea, a well-known adductor for linear compounds was successfully utilized for inclusion of Coenzyme Q10 through a modified technique using oleic acid as rapidly adducible endocyte. Formation of Coenzyme Q10 urea co-inclusion compounds was confirmed by FTIR, DSC and XRD. Optimization of formulation in the preparation of Coenzyme Q10 urea co-inclusion compounds was achieved by a 2² level factorial design. The co-inclusion compounds were found to exhibit good content uniformity. Through the formation of co-inclusion compounds of urea; it results in achieving steep improvement in the dissolution profile of Coenzyme Q10 and marked increase in its photo stability.
Keywords: Adduction, Content uniformity, Dissolution, Coenzyme Q10, Factorial design Urea inclusion compounds.