Preparation and Evaluation of Physical properties Ibuprofen matrix tablet using Tamarand indica as colon targeted drug

Prashant Patil^1*, S.N.Sriharsha¹, Yashwant Kumar.D¹, K.S.S.N. Neelima^2
1Pacific College of Pharmacy, Pacific University (PAHER), Udaipur, India
²SARC- (Scientific and Applied Research Centre) – Hyderabad

Abstract
The present study was undertaken to assess the potential of Tamarind seed polysaccharide (TSP) to act as a biodegradable carrier for colon specific drug delivery. Hence an attempt was made to develop matrix tablet based formulation using TSP which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. . The matrix tablets were prepared by dry granulation technique containing different concentrations (20% mg to 120% mg Quantity per each matrix tablet) of TSP using Ibuprofen as a model drug. The matrix tablets were evaluated for different  quality  control  tests,  content  uniformity  and  in­vitro  drug  release  study. Drug release studies were carried out in 0.1M HCl, pH 6.8 Sorensen phosphate buffer (SPB) and pH 5.9 phosphate buffer saline without rat caecal content. The drug release studies were carried out for 21 hours since the usual colonic transit time is 20−30 hours. Samples, 1ml, were  taken  at  different  time  intervals  and  volume  was  made  up  to  10  ml  with SPB, filtered and absorbance was measured at 221 nm. The prepared Ibuprofen matrix tablet using various proportion of Tamarind indica gum were evaluated for drug release profile for Colon Targeted Drug Delivery System. The per cent drug release in pH 6.8 SPB was more than 0.1M HCl. The result showed that, the matrix formulation F4 released almost the entire quantity of the drug at the end of 24 h dissolution study. It appears from these results that F4 could target ibuprofen to colon.
Keywords: Colon specific drug delivery, Tamarind seed polysaccharide, Matrix tablets, Biodegradable carrier, Enzyme induction