Preparation and characterization of Metronidazole and Minocycline HCl Mucoadhesive Gel for the Treatment of Periodontitis

¹D.K.Borole^*, ¹S.N.Sriharsha, ¹Yashwant Kumar.D, ²K.S.S.N. Neelima 
¹Pacific College of Pharmacy, Pacific University (PAHER), Udaipur
²SARC- (Scientific and Applied Research Centre) – Hyderabad, India

Abstract
The aim of the paper was to develop Metronidazole and Minocycline HCl containing mucoadhesive gel for the treatment of periodontitis. Different Mucoadhesive gels were prepared, using various gelling agents like, Hydroxy ethyl cellulose (HEC), Methyl cellulose (MC) and Poloxamer 407. The selected formulations were studied for different mechanical properties, such as product hardness, compressibility or spreadability and cohesiveness the other characterizations like mucoadhesive, rheology. In vitro Metronidazole release from the prepared formulations was also determined. The gels containing 10% HEC need low work of syringeability but drug(s) release lasts only 24-36 hrs. However, products with 30% (w/w) HEC not only have suitable mechanical properties but show sustained release profiles for 46-58 hrs. Increase the polymer concentration of HEC increased the k value more effectively than MC. So, this work confirmed the acceptability and effectiveness of Metronidazole and Minocycline HCl gel for treatment of periodontitis.
Keywords: Mucoadhesive gel, periodontitis, Metronidazole, Minocycline HCl, texture analysis