Monday , 20 May 2019

Plant Polyamines as Therapeutic Agents: A Review

G. Sindhu*, B. Ramu, T. UshaKiran Reddy
S.V.U College of Pharmaceutical Sciences, S.V. University, Tirupati, A.P, India

Polyamines are aliphatic amines, synthesized in all eukaryotic cell in minutes quantities. Their roles are critical for survival and increase in the conditions of stress. Various studies revealed that, they have significant roles in the health and disease. They are found in high quantities in ischemia, malignancy and other pathological states. But it was not clearly evaluated that elevated levels of polyamines causing the disease or they increase due to negative feedback mechanisms. But their external supplementation improved the conditions of wound healing, proliferation, anti-oxidant, and regulated gene expression andinflammation.Synthetic polyamines (putrescine, spermine and spermidine) are evaluated for their role in health disease. In the same way,Polyamine plant extracts can produce significant quantities of polyamine with the principle molecules of PUT, SPDM and SPM besides the other polyamines. Such extracts need to be tested in various disease conditions to study and to quantification of each polyamine with respect to the other one would be useful in understanding the roles of the polyamines in health and disease. This review describes how a plant derived polyamine extract can be used in treatment for diseases.
Keywords: Polyamines, Putrescine, Spermidine, Spermine.

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