Surendra. K*1, Pankaj Sharma2, B. Anitha3, D. Yashwanth Kumar3
1Pacific University, Udaipur, Rajasthan, India
2Jaipur National University, Jaipur, Rajasthan, India
3SARC (Scientific and Applied Research Center), Hyderabad
A B S T R A C T
Medicinal plants play an important role in the development of potent therapeutic agents. The preliminary phytochemical study revealed that the aqueous and ethanolic extracts of Litchi chinensis fruit were rich in terms of alkaloids, carbohydrates, mucilage except non-reducing polysaccharides moiety. The cardiac and saponin glycosides were present while the anthraquinone and cynogenetin glycosides were absent. Yet the extracts were rich with steroidal moiety, the fat and oil related phytochemical test does not confirm their presence. As the extracts dose up to the 5000 mg/ kg b.w. did not showed any toxic impact on experimental animals, hence the treatment dose for all experimental purpose was selected as 500 mg /kg. b.w. i.e. 1/10th of the maximum safer dose. Concurrently the extracts were analysed for the therapeutic responses against the induced pain as analgesic, induced inflammation as anti-inflammatory, and for effect on CNS using different animal models. Furthermore the extracts were subjected for estimation of their pharmacological values. Prior that the protocol was prepared submitted and approved with institutional animal ethics committee of CPCSEA. All the procedure was carried out according to standard guideline and as per the approved protocol. The acute toxicity study was carried out as per OECD guidelines to decide dose of the extracts. On the basis of these results we can conclude here that the analgesic, anti-inflammatory and CNS depressant effect of these extracts might be due to present phenolic constituents and more appropriately due to flavonoid contents. Still the research work is required to determine the mechanism of action at molecular level.
Keywords: Litchi chinensis fruit, Ethanolic extract, Analgesic, Anti-inflammatory and CNS depressant.