Makwana Rajeshree*1, Patel Harsha1, Patel vishnu2
1Department of Pharmaceutical technology, Indukaka Ipcowala College of Pharmacy, New V.V.Nagar-388121, Gujarat, India
2 Department of Pharmaceutics, R.C. A.R.college of pharmacy and gathel institute of pharmacy, V.V.Nagar-388120, Gujarat, India
Normal topical preparations have some disadvantages like unpleasant odour, greasiness, and skin irritation reported in study cases. Many topical preparations fail to reach the systemic circulation in sufficient amounts in few cases. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is an area of research that is successively done by the microsponge delivery system. This problem is achieved by the present formulation as microsponge in the areas of research. MDS is a microscopic sphere capable of absorbing skin secretions, therefore reducing the oiliness of the skin. Microsponge having particle size of 10-25 microns in diameter, have wide range of entrapment of various ingredients in a single microsponges system and release them at desired rates. Drug release in microsponge is done by the external stimuli like (pH, temperature, rubbing). It has several advantageous over the other topical preparations are non allergenic, non toxic, non irritant, non mutagenic reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility.These MDS’s are closely related to microspheres, and used in the sun screens, gel, creams, cosmetics, prescription products, ointments, (OTC) over- the-counter skin care preparations, recently used in oral drug delivery Microsponge used for photostability.
Keywords: Microsponge, microspheres, oral delivery