Saturday , 22 September 2018

Pharmacological Screening of Premna Latifolia against High Fructose Diet Induced Insulin Resistance, Hyperlipidemia and Obesity in Male Wistar Rats

Kongi Kavyasudha*, Mubarak Yagoub Bashar Abdelmoula, Ballavolu Sandeep
Sree Venkateswara University, Tirupati.

Insulin is a natural hormone made by the pancreas that controls the level of the sugar glucose in the blood. Insulin permits cells to use glucose for energy. Cells cannot utilize glucose without insulin. Insulin stops the use of fat as an energy source by inhibiting the release of glucagon. With the exception of the metabolic disorder diabetes mellitus and Metabolic syndrome, insulin is provided within the body in a constant proportion to remove excess glucose from the blood, which otherwise would be toxic. When control of insulin levels fails, diabetes mellitus will result. As a consequence, insulin is used medically to treat some forms of diabetes mellitus. Patients with type 1 diabetes depend on external insulin (most commonly injected subcutaneously) for their survival because the hormone is no longer produced internally. Patients with type 2 diabetes are often insulin resistant and, because of such resistance, may suffer from a “relative” insulin deficiency. These findings investigated that the insulin resistance has been increased in the diabetic control group when compared to the control groups, as insulin resistance index is high in diabetic control group, in all other groups the insulin resistance index is decreased when compared with diabetic control so insulin resistance is decreased. The lipid profile was significantly increased in diabetic control group when compared to the control group and in all others groups the levels were decreased. but the HDL level was decreased in diabetic control group and increased in all others groups. The body weight of the animals was increased in the diabetic control group and the increase was very high. when compared to all other groups.

Keywords: Diabetic control, Insulin, Diabetes mellitus, Metabolic syndrome

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