Wednesday , 8 April 2020

Pharmacological Evaluation of Pavonia Odorata Willd for Analgesic, Anti-Inflammatory and Anti-Ulcer Activity

G.T. Jyostna1Murali Sollu2, Dr. Gampa Vijay Kumar3
1,2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

A B S T R A C T
The plant Pavonia odorata willd (Malvaceae) contains many active ingredients like ageratochromene, palmitic acid, hexahydrofarnesyl acetone, beta-eudesmol and beta-caryophyllene oxide as the major constituents. It is reported to have Analgesic Activity, Antibacterial Activity, Antifungal Activity, Antimicrobial, Antioxidant, Antiulcer Activity, Anti-inflammatory Activities and Reduction in Blood Pressure. It is been widely used in traditional system of medicine in India. Objective: The present study was aimed at evaluating the metabolic extract of aerial parts of Pavonia Odorata Willd at doses of 100 and 200 mg/kg body weight for analgesic, anti- inflammatory and antiulcer activities. Methods: The Analgesic activity was evaluated by hot Plate model.  Anti-inflammatory activity (sub acute) of Pavonia odorata willd methanolic extract was evaluated by carrageenan induced hind paw edema. Aspirin induced ulcer model were employed for evaluating antiulcer activity for methanolic extracts of Pavonia odorata willd. Result: Methanolic extracts of Pavonia odorata willd was evaluated for Analgesic activity by hot Plate model. Methanolic extracts of Pavonia odorata willd produced anti-inflammatory activity at the various time intervals (1, 2, 3, 4, 5 and 24h) when it was evaluated for by carrageenan induced rat paw edema model. POM at both the doses exhibited good anti ulcer activity in aspirin induced ulcers model.
Keywords: Pavonia odorata willd –Analgesic, Anti-inflammatory; Antiulcer

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