Kalangi Deepikanjali, P. Naresh Babu*
Department of pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore (Dist) 524346, Andhra Pradesh, India.
A B S T R A C T
The Plant Cynodon dactylon Family (Graminae/Poaceae) is extensively used in clinical practice but it has various pharmacological activities have been reported. It is a very familiar plant almost available in the entire world. In ethno medicinal practices, the plant Cynodon dactylon used in the treatment of various diseases and has pharmacological action. Treatment with Triton-X-100 caused a significant rise in the levels of Total Cholesterol in Group-II, Group-III Group-IV Group-V Group-VI (i.e Hyperlipidemic Control, MECD 500 mg/kg, PECD 400 mg/kg, PECD 500 mg/kg, & Standard (Atorvostatin) 10mg/kg) and the levels were found to be 192.47 ± 5.05, 175.28 ± 4.43, 180.97 ± 5.21,187.86 ± 9.66, and 180.79 ±9.1, respectively. Administration of various doses of the MECD & PECD after the Induction with Triton-X-100 resulted in the decreasing of Cholesterol levels. MECD at dose of 500mg/kg were 27.1 ± 2.99 and groups treated with PECD at dose of 400mg/kg and 500mg/kg showed a dose dependant increase in the HDL-C levels 31.04 ± 4.32 and 33.15 ± 2.51 respectively. In Atorvastatin group the HDL-C was elevated to 39.18 ± 3.14. . The liver function tests involve mainly the determination of LDH and any marked necrosis of the liver cells lead to a significant rise of these enzymes in the serum. The Scavenging activity of the extract towards DPPH radicals when compared with standard ascorbic acid. IC50 value for standard Ascorbic acid was found to be 43.137µg/ml, where as the IC50value for phenolic extract of PECD was found to be 41.024 µg/ml.
Keywords: Cardioprotective, Plant extract, pharmacological, Screening.