Dr. Gampa Vijay Kumar*1, Dr Y. Sridhar2, Baikadi Ravi3
1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2Professor KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
3KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
A B S T R A C T
In the presant work an attempt has been made to investigate the anti inflammatory and analgesic properties of the hippeastrum vittatum plant methanolic fractions. The development of edema in the paw of the mice after injection of carageenan is a biphasic event. The initial phase of the edema has been attributed to the release of histamine and serotonin, the edema maintained during the plate au phase to kinin like substances and the second accelerating phase of swelling to the release of prostaglandin like substances. Inhibition of edema observed in various inflammatory models induced experimentally in the present study may, therefore be attributed to the ability of the Hippeastrum vittatum to inhibit various chemical mediators of inflammation like histamine and 5-HT during the initial phase. In the present study Hippeastrum vittatum significantly increased the reaction time in hot-plate test suggesting its central analgesic activity; the probable mechanism could be by inhibition of prostaglandin synthesis. Prostaglandins play significant role in different phases of inflammatory reactions and elicit pain by direct stimulation of sensory nerve endings and also sensitize sensory nerve endings to other pain provoking stimuli. The findings in this study suggest that the hippeastrum vittatum possess anti-inflammatory and analgesic activity. The results have been obtained in carefully controlled experiments with laboratory animals where psychological factors can presumably be ruled out. In all the tests the responses have been assessed by actual measurement and not by subjective comparisons which may be influenced by the observer. Therefore the statistical validity of the findings has been proved and they provide a scientific found ationfortheuse of the biologically active ingredients of hippeastrum vittatum in inflammatory and pain conditions and explain the clinical effectiveness of the hippeastrum vittatum.
Keywords: Hippeastrum vittatum, inflammatory, vittatum