Mallikarjun Vasam*1,Dr. S.N. Sri Harsha2, K.S.S.N. Neelima2, D. Yashwanth Kumar2
1Pacific University, Udaipur, Rajasthan, India
2SARC (Scientific and Applied Research Center), Hyderabad, India
A B S T R A C T
The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, cefdinir, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material. Microspheres were prepared by solvent evaporation method using an acetone / liquid paraffin system. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well by Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. The in vitro release studies were performed in pH 6.8, phosphate buffer. Pharmacokinetics was evaluated after parenteral administration so as to determine the sustained action of the drug after one-time administration of the formulation in a rat model.
Keywords: In-vitro release, microspheres, pharmacokinetics, cefdinir