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Amit Agrawal*, Ameeta Argal
1Research Scholar, Institute of Pharmaceutical Science & Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004
2Professor, TIT College of Pharmacy, Bhopal, Madhya Pradesh, India-462042.
A B S T R A C T
Gymnema sylvestre (Asclepiadaceae), known as “gurmar” for its distinct property as sugar destroyer, is a reputed herb in the Ayurvedic system of medicine. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. Leaves is green, 2 to 6 cm long, 1 to 4 cm in diameter, Odour is characteristic, taste slightly bitter. It has been used in various Asian traditional medicines for the treatment arthritis, diuretic, anemia, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation, microbial infections, indigestion, and anti-inflammatory. G. sylvestre has good prospects in the treatment of diabetes as it shows positive effects on blood sugar homeostasis, controls sugar cravings, and promotes regeneration of pancreas. The aim of the study is to cover the pharmacognostical ,preliminary phytochemical screening and Micromeretics properties Gymnema sylvestre Leaves Preliminary phytochemical examination of extracts of Gymnema sylvestre Leaves shows the presence of Alkaloid, carbohydrates, Glycosides and Steriods and Triterpenoids. Physicochemical parameters of fruit of the plant are like foreign organic matter (2.1%), total ash (8.44% w/w), acid insoluble ash (3.78% w/w) water soluble ash (25.12% w/w) Moisture content (2.23%) and Swelling index (2.90%) were found. Alcohol soluble extractive (18.92%), aqueous extractive values (25.12%) and pet-ether extractive values (11.50%) were found respectively. Micromeretic parameters were also determined and angle of repose (29.97), Bulk density (0.32), Tapped density (0.48), Carr’s Index (30.30) and Hausner’s Ration (1.28) were found respectively. In these present investigations, various pharmacognostical standization parameters such as macroscopy, microscopy and preliminary phytochemical screening were carried out which could be helpful in authentification Gymnema sylvestre Leaves. The result of the present study will also serve as reference material in the preparation of herbal monograph.
Keywords: Gymnema sylvestre, Asclepiadaceae, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation
