Pharmacodynamic and Pharmacokinetic Drug Interaction of Risperidone with Pioglitazone

Bhupalam Pradeep kumar*¹, Y. Padmanabha Reddy², N. Devanna^3
1Department of Pharmacology, Center for Pharmaceutical Research, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721, Andhra Pardesh, India.
²Principal, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721, A.P, India.
³Principal, JNTUA College of Engineering, Kalikiri-515234, Andhra Pardesh, India.

A B S T R A C T
The present study was performed to investigate the effect of risperidone on the pharmaco dynamic and pharmacokinetics of pioglitazone to evaluate the safety and effectiveness of the combination. The blood samples were collected and analyzed for estimation of blood glucose levels by GOD/POD method as well as Pioglitazone was estimated for pharmacokinetic data.  The risperidone alters the pharmacokinetics of pioglitazone and produces hypoglycaemic effect. Risperidone appears to produce interaction with pioglitazone by pharmacokinetic and pharmacodynamic mechanisms.
Keywords: risperidone, pharmacokinetics, pioglitazone.