One-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones using Cerium chloride as a catalyst and Its Biological Activity

Balusu Phani Kumar*¹, V.S.R. Prasad¹, A. Jaya shree^2
1Mylan Laboratories Limited, Hyderabad, Telangaana India.
²Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India.

A B S T R A C T
An efficient synthesis of 3,4-dihydropyrimidinones using Cerium  chloride hepta hydrate as a catalyst from an aldehyde, beta-keto ester and urea in ethanol is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56–97%).and its biological activity was determined by using Disc Diffusion method.
Keywords: Biginelli reaction, dihydropyrimidinones, cerium chloride heptahydrate, one-pot condensation, Anti microbial and Anti fungal Activity, Synthesis.