Wednesday , 29 March 2017

One-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones using Cerium chloride as a catalyst and Its Biological Activity

Balusu Phani Kumar*1, V.S.R. Prasad1, A. Jaya shree2
1Mylan Laboratories Limited, Hyderabad, Telangaana India.
2Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India.

A B S T R A C T
An efficient synthesis of 3,4-dihydropyrimidinones using Cerium  chloride hepta hydrate as a catalyst from an aldehyde, beta-keto ester and urea in ethanol is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56–97%).and its biological activity was determined by using Disc Diffusion method.
Keywords: Biginelli reaction, dihydropyrimidinones, cerium chloride heptahydrate, one-pot condensation, Anti microbial and Anti fungal Activity, Synthesis.

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