MOMETASONE FUROATE CREAM

ABOUT AUTHOR
P. Sri chandana*, S. Amani, P. Sivaleela
B.Pharmacy
Narayana Pharmacy College, chinthareddypalem, Nellore, A.P, India
E-mail: [email protected]

ABSTRACT
Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity. Chemically, mometasone furoate is 9α, 21-Dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-(2-furoate), with the empirical formula C27H30CI2O6, a molecular weight of 521.4 Mometasone furoate is a white to off-white powder practically insoluble in water, slightly soluble in octanol, and moderately soluble in ethyl alcohol. Each gram of mometasone furoate cream USP 0.1% contains: 1 mg mometasone furoate, USP in a cream base of hexylene glycol, phosphoric acid, propylene glycol stearate (55% monoester), stearyl alcohol and ceteareth-20, titanium dioxide, aluminum starch octenylsuccinate (Gamma Irradiated), white wax , white petrolatum, and purified water. Repigmentation of 90-100% was achieved in more than 80% of patients with vitiligo of the face and more than 60% of patients with vitiligo on other part of the body.
Key words: Mometasone furoate, octenylsuccinate, re pigmentation.
INTRODUCTION
Vitiligo is a common idiopathic acquired heritable melanocytopenic depigmentation Disorder. The disorder results in substantial cosmetic disfigurement, particularly in dark-skinned patients. It appears to be a common condition with general incidence reported to be one percent. In recent years, several studies have indicated that the topical applications of corticosteroid preparations may promote repigmentation in the lesions of vitiligo. Mometasone furoate is a non fluorinated topical corticosteroid with high potency and safety profile. This study was designed to evaluate the efficacy as well as safety profile of mometasone furoate in childhood vitiligo. Patients were advised to apply mometasone furoate 0.1% ointment once a day for six months or till complete repigmentation whichever was earlier. Patients were followed up at monthly intervals. They were carefully observed for any cutaneous, ocular or systemic side effects. Complete repigmentation in this study meant the repigmentation of more than 90% of the total area of the tested patches of vitiligo and partial pigmentation meant beginning of perifollicular and marginal erythema and pigmentation.
MECHANISM OF ACTION:
Like other topical corticosteroids, mometasone furoate has anti-inflammatory,anti-pyritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is   released from membrane phospholipids by phospholipase A2.
DOSAGE
Apply a thin film of mometasone furoate cream USP, 0.1% to the affected skin areas once daily. Mometasone furoate cream USP, 0.1% may be used in pediatric patients 2 years of age or older. Since safety and efficacy of mometasone furoate cream USP, 0.1% have not been adequately Established in pediatric patients below 2 years of age, its use in this age group is not recommended. As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Safety and efficacy of mometasone furoate cream USP, 0.1% in pediatric patients for more than 3 weeks of use has not been established. Mometasone furoate cream USP, 0.1% should not be used with occlusive dressings Unless directed by a physician. Mometasone furoate cream USP, 0.1% should not be applied in the Diaper area if the child still requires diapers or plastic pants as these garments may constitute occlusive dressing.
SIDE EFFECTS:
Just like any medicine, mometasone furoate cream can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. Some of the potential side effects of mometasone furoate cream may include skin irritation, such as burning, itching, and stinging. In most cases, reactions to this medicated skin cream tend to be minor and easily treated. However, there are also some problems that are potentially serious and should be reported to a healthcare provider right away, including difficulty breathing, severe fluid retention, or infections. If you show signs of absorbing mometasone topical through your skin, such as:
blurred vision,
sleep problems (insomnia)
weight gain, puffiness in your face
muscle weakness, feeling tired
Less serious side effects may include
mild skin rash, itching, burning, redness or dryness
thinning or softening of your skin
skin rash or irritation around your mouth
swollen hair follicles
spider veins
Numbness or tingling
changes in color of treated skin
blisters, pimples, or crusting of treated skin
Stretch marks.
CONCLUSION: The mechanism of the beneficial effects of corticosteroids in cases of vitiligo remains uncertain. The finding of an increased incidence of auto antibodies in patients with vitiligo, suggests a possible autoimmune basis for the disease. Topical steroids may locally suppress the immunologic changes allowing inactive melanocytes to repopulate affected skin sites. Melanocytic density of facial skin is also higher   than skin of trunk and limbs. Thus, larger number of residual melanocytes in unaffected facial skin may further explain the better results of repigmentation on the face. The results of this study indicate that a strong non fluorinated steroid, mometasone furoate, is a useful agent for treatment of childhood vitiligo without any local or systemic side effects.