Matrix Diffusion Controlled Release Tablets of Repaglinide-Formulation and In-vitro Evaluation

P. Suresh1*, U. Venkatesh1, P. Anwar Basha1, B. Yogesh, G. Sravan reddy2
1St John’s College of Pharmacy, Yemmiganur, Kurnool, Andhra Pradesh
2Hi-Q Herbals, Kothapet, Hyderabad, Telangana

A B S T R A C T
The purpose of present reaserch work was to prepare and evaluate the controlled release tablets of Repaglinide. Direct compression method was used to prepare the tablets using different polymers include Eudragit S-100, Eudragit RSPO, Eudragit RLPO, Eudragit L-100, HPMC K4M and HPMC K15M. Formulations were prepared by varying the amount of polymers. The prepared tablets were (F1-F12) evaluated for both precompression and postcompression parameters. The compatability of drug with polymers is identified by FTIR studies. The resulta obtained showed that the drug is compatible with all the polymers used.
Keywords: Repaglinide, Eudragit S-100, Eudragit RSPO, Eudragit RLPO, Eudragit L-100, HPMC K4M and HPMC K15M, Direct compression method