K. Jyothsna Jayaraju*, N. Bhasker Babu, S. Rubina, R. Mohana Priya, S. Neelofar Sulthana, SK. Rubina
Dr. K.V. Subba Reddy Institute of Pharmacy, Near Dupadu Railway station, Dupadu, Kurnool, Andhra Pradesh.
A B S T R A C T
Pandanus Odoratissimus is the most significant genus in the family Pandanaceae, which is commonly known as Screw pine (or) Kewda in India. This study evaluates anthelmintic activity of methanolic root extract of Pandanus odoratissimus on Indian adult earthworms, Pheretima posthuma (annelid). Roots were extracted by using soxhlet apparatus. Phytochemical screening of crude extracts showed the presence of tannins, phenolics, flavanoids, terpenoids, steroids and proteins. Various concentrations (25, 50, 100mg/ml) of crude extracts were tested for anthelmintic activity which involved the determination of the time of paralysis and time of death of worms. The activity was compared with standard piperazine citrate. The methanolic extract showed significant activity when compared to the standard piperazine citrate. The paralysis and death time is 48, 27, 17 and 76, 52, 30 minutes respectively at concentrations 25, 50 and 100mg/ml, whereas 32, 19, 11 and 62, 40, 21 minutes respectively for piperazine citrate. In order to confirm the studies in vivo studies have to be conducted.
Keywords: Pandanus odoratissimus, anthelmintic activity, Piperazine citrate