Thursday , 26 April 2018

An Inherited Genetic Blood Disorder: Thalassemia

D. Pragathi*, Ramesh Dhani, M. Gobinath
Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India

Abstract
Thalassemia is an inherited blood disorder characterized by less oxygen-carrying protein (haemoglobin) and fewer red blood cells in the body than normal. It is most common type of haemoglubinopathies transmittedby hereditary. It includes HBA1 and HBA2 genes. Alpha thalassemia involves in decreased alpha-globin production whereas beta thalassemia due to mutations in HBB gene on chromosome. The severity of thalassemia occurs with complications of including iron overload, bone deformities and CVSillness. It results in excessive destruction of RBC which leads to Anemia. Thalassemia leads to cause liver disease and followed by heart failure and even may leads to death.
Keywords: Thalassemia, hemoglubinopathies, hereditary, mutations, anemia.

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