Bhupalam Pradeepkumar1*, Y. Padmanabha Reddy 2,N. Devanna3
1Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721, Andhra Pardesh, India.
2Principal, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721, A.P, India.
3Principal, JNTUA College of Engineering, Kalikiri – 515234, Andhra Pradesh, India.
A B S T R A C T
The present study was performed to investigate the effect of olanzapine on the pharmaco dynamics and pharmacokinetics of pioglitazone in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination. The blood samples were collected and analyzed for estimation of blood glucose levels by GOD/POD method and serum pioglitazone levels by HPLC method for pharmacokinetic data. The olanzapine alters the pharmacokinetics of pioglitazone and found to enhance the hypoglycaemic effect pioglitazone. Olanzapine appears to produce pharmacokinetic interaction with pioglitazone which might be by inhibiting the metabolism of pioglitazone.
Keywords: Pioglitazone, olanzapine, diabetes, Pharmacokinetic and pharmacodynamic drug interaction