Hypoglycaemic and Hypolipidemic Activity of Aqueous Extract of Bauhinia Purpurea Flower in Streptozotocin-Induced Diabetic Rats

Md. Sultan Ali, K. Suresh*, Y. Suresh, Vijaya Lakshmi
Safa College of Pharmacy, Kurnool, Andhra Pradesh, India-518218

A B S T R A C T
The aqueous extract of Bauhinia purpurea flower (AEBPF) was tested for its hypoglycaemic and hypolipidemic activity by sub acute treatment method in streptozotocin-induced diabetic rats.  Blood  glucose  levels  were determined  after  oral administration of two concentrations of AEBPF (200 and 400 mg/kg) at  0^th,  10^th and 1^5th  day and biochemical parameters like glycosylated haemoglobin, serum protein, serum creatinine and lipid profile were estimated after 14 days of sub acute study. The results revealed  that in sub acute treated  groups  administration  of a low dose of 200mg/kg reduced blood glucose level with less significance (p<0.05) but a high dose of 400mg/kg reduced blood glucose significantly (p<0.01).In addition, changes in body weight, glycosylated haemoglobin, serum protein, serum creatinine and serum lipid profile levels assessed in the extract treated diabetic rats were compared with standard control, diabetic control and normal animals in sub acute treated groups. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine.
Keywords: Bauhinia purpurea flower, Hypoglycaemic activity, Hypolipidemic activity, Streptozotocin; Lipid profile.