Hepatoprotective Activity of Methanolic Extract of Barleria Montana Nees Leaves in Paracetamol Induced Rat Hepatic Injury

Gunji Venkateswarlu*¹, G. Swarupa Rani², M. Vani³, Naga Prashant. K^4
1*Assistant Prof, Department of Pharmacognosy, Narasaraopeta Institute of Pharmaceutical sciences, Narasaraopet, Guntur, Andhra Pradesh, India.
²Assistant Prof, Department of Pharmacology, Narasaraopeta Institute of Pharmaceutical sciences, Narasaraopet, Guntur, Andhra Pradesh, India.
³Asst. Professor, Department of Pharmacognosy, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.
⁴Assistant Prof, Department of Pharmaceutical Chemistry, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur, Andhra Pradesh, India.

A B S T R A C T
The present study was undertaken to investigate the protective effect and possible mechanism of methananolic extract of Barleria Montana Nees (BM) on paracetamol indued rat. This respective activity was assessed through monitoring liver function tests through the measurement of triglycerides, cholesterol, total protein, total bilirubin, serum enzymes like SGOT and SGPT and in vivo antioxidant parameters like lipid peroxidase, Superoxide dismutase (SOD) and catalase. Further hepatic tissues were also subjected to histopathological studies. Pretreatment of BM methanolic extract (500mg/kg) reduced the fatty liver symptoms and significantly (p<0.001) inhibited the increase of respective serum enzyme levels. The results of the present study indicated that BM methanolic extract possess Hepato protective effects which could act as an effective treatment for acute hepatic diseases.
Keywords: Barleria Montana Nees, paracetamol, methananolic extract, hepatic diseases.