Dr. M.V. Ramana1, Radhika Padarthy2
1Principal, Gurram Balanarasaiah Institute of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy–501 301.
2Research Scholar, Department of Pharmaceutics, JNTU Hyderabad, Telangana
A B S T R A C T
In the present study Atovaquone solid dispersions were prepred in order to improve the bioavailability and solubility of the drug by using PVP, PEG 5000, Poloxamer 188 as hydrophilic carriers and Gelucire 44/14 and Gelucire 50/13 as lipophilic carriers. Aerosil 380 was selected as inert carrier in case of solid dispersions prepared with lipophilic carriers. Ratio of drug to polymer was varied from 1:1 to 1:5. Melting and Solvent evaporation method was followed. From the results of comparative dissolution studies conducted between optimized formulations, pure drug and marketed formulations, it was concluded that formulations prepared with gelucire 44/14 (ASD 24) have shown greater drug release than remaining formulations. From the results of In vivo studies conducted between final optimized formulation of each drug, pure drugs and marketed formulation of Atovaquone, it can be concluded that bioavailability of final optimized formulation was higher than the marketed formulation as well as pure drug.
Keywords: Atovaquone, Solvent evaporation method, solid dispersions, PVP, PEG 5000, Poloxamer 188