Saturday , 22 September 2018

Formulation and In-vitro Evaluation of Fluvastatin Sustained Release Tablets

Dr. T. Satyanaraya, B. Sushma, P. Swathi, A. Narayana Rao, J. Kumar Raja
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Telangana-507303

Abstract
The aim of the present study was to develop sustained release formulation of Fluvastatin   to maintain constant therapeutic levels of the drug for over 12 hrs. Various natural polymers such as Guar gum Sodium CMC and Chitosan were employed as polymers. Fluvastatin dose was fixed as 20 mg. Total weight of the tablet was considered as 150 mg. Polymers were used in the concentration of 25, 50 and 100 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,96.10 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Fluvastatin, Guar gum, Chitosan, Sodium CMC and sustained release tablets.

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