Formulation and In-vitro Evaluation of Dofetilide Fast Dissoloving Tablets

Narayana Rao Alla*, Usha Tatikonda, Dr. Satya Narayana Tanuku
Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India

ABSTRACT
The present study was aimed to formulate fast dissolving tablets of Dofetilide. In the present work Sodium starch glycollate, Cross povidone and Cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 98.16 % in 30 min hence it is considered as optimized formulation. The F4 formulation contains Cross povidone as super disintegrate in the concentration of 5 mg.
Keywords: Dofetilide, Oro dispersible tablets, Super disintegrating agents, Direct compression