FORMULATION OPTIMIZATION AND EVALUATION OF LIPOSOMAL GEL OF PREDNISOLONE BY APPLYING STATISTICAL DESIGN

ABOUT AUTHOR
Varde Neha M*, Joshi Darshana P, C.Sini Srendran, Shah Viral H, Upadhyay U.M.
Sigma Institute of Pharmacy, Bakrol, Vadodara, India
E-mail: [email protected]

ABSTRACT
Prednisolone which is intended to use in various disease shows severe side effects on oral administration due to shorter half life. The drug also is not suitable to be given parenterally due to rapid clearance. The present research work was aimed to deliver Prednisolone transdermally by encapsulating in lipid vesicle. The liposomal formulation of Prednisolone was prepared and optimized following BBD. In which Soya Lecithin, DPPC and Cholesterol taken as independent variables at 3 different levels. The so prepared liposomal formulation was characterised for parameters like Mean Particle size, %EE and T₈₀%. The result of stability studies indicate thatliposome so formed were carried out. So, Optimized liposomal formulation converted into gel using Carbopol 940 using 1.5% Concentration. The Liposome gel was evaluated for Skin Permeation, Viscosity and the gel with most desirable properties was kept for stability study for a period of 60 days which indicate that formulation is stable.
Key words: Liposomal Suspension, Gel, BBD, Prednisolone, Topical application