Yeduru Krishna Reddy*1, Dr. Shailesh Sharma2
1Pharmaceutical Sciences, NIMS Institute of Phrmacy, NIMS University, Shobhanagar, Jaipur, Rajasthan
2Associate Professor, NIMS Institute of Phrmacy, NIMS University, Shobhanagar, Jaipur, Rajasthan
A B S T R A C T
Non-ionic surfactant based Proliposomal Gels of naproxen sodium, an cox II inhibitor, were prepared by coacervation phase separation method. The prepared systems were characterized for encapsulation efficiency, shape, size and in vitro drug releas e. Stability study was carried out to investigate the leaching of drug from the Proliposomal system during storage. The results showed that naproxen in all the formulations was successfully entrapped and a substantial change in release rate and an alteration in the encapsulation efficiency of naproxen from Proliposomal were observed upon varying the type of surfactant and cholesterol content. The encapsulation efficiency of Proliposomal prepared with Span 40:60 was superior to that prepared with all Span preparation. A preparation with Span 40:60, cholesterol and lecithin gave maximum encapsulation efficiency (84.61%) and release results (Q12h= 96%) as compared to other compositions. Proliposomal formulations showed fairly high retention of naproxen inside the vesicles at refrigerated temperature (4-80 C) up to 1 month.
Keywords: Naproxen, Proliposomal, encapsulation efficiency, drug delivery.