Tuesday , 20 March 2018

Formulation and Evaluation of Zafirlukast

Katta Sridhar*, Kongi Kavya Sudha, Ballavolu Sandeep, Chirumanu Ramadevi
Swathi College of Pharmacy, Venkatachalem, Nellore, Andhra Pradesh, India

Development of chewable tablets containing different pharmaceutical compositions with simple manufacturing procedures using different excipients. Zafirlukast is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. Zafirlukast chewable tablets were prepared by both wet granulation and direct compression methods using suitable excipients. The granules were evaluated for pre-compression parameter. The formulated tablets were evaluated for post – compression parameters. Ideally chewable formulations should have smooth texture upon disintegration, pleasant taste and no bitter or unpleasant after taste. Chewable tablets facilitate more rapid release and hence more rapid absorption of active ingredients and provide quick onset of action. The in-vitro release study of formulation F7 showed 98.8%drug release at the end of 30 min.

Keywords:  Zafirlukast, chewable tablets, granules, Mannitol, Crospovidone, Magnesium Stearate.

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