Wednesday , 5 August 2020

Formulation and Evaluation of Mouth Dissolving Tablets of Betamethasone Using Sublimation Method

K. Swathi*, M. Vijaya Laxmi
Department of Pharmaceutics, Teegala Krishna Reddy College Of Pharmacy, Meerpet, Saroornagar, Hyderabad-500 097

A B S T R A C T
In the present research work mouth dissolving tablets of betamethasone by direct compression method and using rotary tablet compression machine (mfg by lab press) using 6mm punches. To enhance the solubility of drug by sublimation method using sublimating agents like camphor and methanol were developed. After the preformulation studies the formulation blends were subjected to evaluation tests of various precompression and postcompression parameters and all the formulations were found to possess good flow properties. The maximum water absorption ratio was shown by formulation F2, F4 showed 98%. F4 formulation which contains camphor as sublimating agent was shown drug release at 15 min. It was found to be 99.45 ± 0.06.
Keywords: betamethasone, sodium starch glycolate, microcrystalline cellulose.

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