V. Bhargavi*, Hindustan Abdul Ahad
Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
A B S T R A C T
Floating drug delivery systems have shown to be of better significance in release rate for drugs having site specific absorption. The present study was an attempt to develop floating tablets of Ciprofloxacin Hcl which on oral administration prolongs its gastric residence time there by increasing bioavailability, diminishing side effects and enhanced patient compliance. Ciprofloxacin HCl is used to treat a number of infections including: infections of bones and joints, endocarditis, gastroenteritis, urinary tract infections, prostatitis, anthrax and chancroid. Ciprofloxacin an antibacterial having narrow absorption window in the upper part of gastrointestinal tract, was formulated as floating tablets using gas generating agent sodium bicarbonate and hydrophilic polymer HPMC K4M, eudrgit 100S, guar gum in different ratio by wet granulation techniques. The biological half life of Ciprofloxacin HCl is 3 to 5 hrs. The drug should be administered twice a day. The prepared formulations were evaluated with pre-compression parameters like bulk density, compressibility index, hausner ratio, angle of repose and postcompression parameters like appearance, weight variation, thickness, hardness, friability, drug content, tablet density, floating test, in-vitro dissolution study, kinetics of drug release. Comparion done by marketed samples shows exact results. The in vitro dissolution study of formulation F4 was 98.28% within 12 hours for good release and was fitted to kinetics of drug release for first, zero orders, korsmeyer peppas models.
Keywords: Ciprofloxacin HCl, Buoyancy, In-vitro dissolution, Release order Kinetics, Floating tablets.