P. Suresh1*, U. Venkatesh1, G. Sravan reddy2
1St John’s College of Pharmacy, Yemmiganur, Kurnool, Andhra Pradesh
2Hi-Q Herbals, Kothapet, Hyderabad, Telangana
A B S T R A C T
The main objective of the present study is the formulation of Fast dissolving tablets of Carvedilol by liquisolid compacts. In this method poorly water soluble drugs like Carvedilol are liquefied by using Solvents like PEG-400, polypropylene glycol and Tween 80 and different formulations were prepared in different ratios, and then mixed with a carrier particle like Microcrystalline cellulose-200, lactose anhydrous, Neusiline and coated by coating materials like Aerosil-200 in different ratios which forms a wet particles. The wet granules are dried uniformly dried and the flow properties of the granules like Carr’s index, Hausner’s ratio and Angle of repose were calculated and the granules were punched. The prepared Tablets was evaluated and weight variation, hardness, friability and Assay were and calculated and noted. The results suggest that the Formulation F12 shows better post and pre formulation properties and the drug release profiles of the optimized formulation and the Marketed Tablets were compared and concluded that the F12 Optimized formulation shows better bio-availability.
Keywords: Neusiline, Tween-80, Aerosil-200, Kyron T-314,Poly ethylene glycol-400, liquisolid compacts.