Wednesday , 5 August 2020

Formulation and Evaluation of Apremilast Topical Gel

Adapa Satish Kumar, Marvathu Subash Chandra Bose, Dr. Tanuku Satyanarayana
Mother Theresa Pharmacy College, Kothuru Village, Sathupally -507303, Khammam, Telangana, India

 A B S T R A C T
In the present work an attempt was being made to formulate and evaluate topical gel containing anti inflammatory drug Apremilast. Carbopol 971, Sodium CMC and carbopol 934 were selected as polymers. The drug and excipient compatability was studied by using FTIR. Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs. All the results were within the limits, by diffusion studies it was observed that formulation F8 shown maximum drug release of 95.49% which was considered as optimized formulation.

Keywords: Apremilast, Topical, Carbopol 971, Sodium CMC and carbopol 934

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