P. Suresh1*, U. Venkatesh1, S. Lakshmana rao 1, P. G. Sravan reddy2
1St John’s College of Pharmacy, Yemmiganur, Kurnool, Andhra Pradesh
2Hi-Q Herbals, Kothapet, Hyderabad, Telangana
A B S T R A C T
The present study is an attempt to develop Orodispersible tablets of Anti hyperlipidemic drug, with superdisintegrates which disintegrates in matter of seconds in the oral cavity, thereby reducing the time of onset of pharmacological action. Direct compression method was used for formulation of orodispersible tablets, microcrystalline cellulose (MCC) and lactose was used as a diluent, Sodium starch glycolate, crosscarmellose sodium and crospovidone were used as superdisintegrates, magnesium Stearate was used as lubricant, neotame as sweetener and orange flavor was used to improve mouth feel. The calibration curve for the estimation of the API was prepared at 247 nm. The method obeyed Beer Lambert’s law in the steady range of 3-10µg/ml with a high R2 value of >0.998 and suggested that the method was reproducible and hence suitable for estimation of API. The API-excipients interaction was studied using FTIR spectroscopy for selected combination of API with different excipients used. The FTIR study reveals that API peaks and API-excipient peaks were not differ, so no API-excipient interactions took place during compatibility study. All the compatibility studies were found to be satisfactory and so formulation trials were started with the selected excipeints. In all formulations the drug release was nearer to 100% within 45 minutes. Formulation T10 showed release (96.09%) in 30 minutes hence T10 was optimized.
Keywords: MCC, Neotame, Crospovidone, Orodispersible tablets