D. Radhika1, G. Mahesh*2
1Department of Pharmaceutics, Vagdevi Pharmacy College, Warangal, Telangana, India
2Department of Pharmaceutical Chemistry, Avanthi Institute of Pharmaceutical Sciences, Hyderabad, Telangana, India
A B S T R A C T
The present investigation aims to design, prepare and evaluate the lozenges and troches of Cefixime using various polymers like HPMC E50, HPMC 15cps, guargum and PVP K30 in different concentrations. The lozenges were prepared by heating and congealing method and the troches were prepared by direct compression method. All the prepared formulations were subjected to various evaluation parameters like hardness, content uniformity, friability, weight variation &in-vitro dissolution. The prepared formulations have a hardness of 8 to 12kg/cm2 (Lozenges), 3 to 5kg/cm2 (Troches), free from gritty particles. The optimized formulations of lozenges using each polymer mentioned above showed in-vitro drug release of 96.6% to 97.75%. The optimized formulations of troches using each polymer mentioned above showed in-vitro release of 97.8% to 98.4%. The lozenges and troches can provide an attractive and alternative formulations in the treatment of bacterial infections for paediatric, geriatric and dysphagic patients.
Keywords: Cefixime, Lozenges, Troches, HPMC E50, HPMC 15cps, PVP K30 and guargum.