Wednesday , 23 August 2017

Formulation Development and In-Vitro Evaluation of Delayed Release Drug Delivery System of Atazanavir Tablets

Kiran Kumar Yada1*, Dharmajit Pattanayak1, Saumya Das1, K. Someshwar2
1Associate Professor, Vikas College of pharmaceutical Sciences, Rayanigudem, Suryapet.
2Manager, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad.

A B S T R A C T
The aim of the present study was to develop delayed release formulation of Atazanavir to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of poly methacrylate polymers was employed as polymers. Atazanavir dose was fixed as 4 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 10, 20 and 30 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 96.33 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Atazanavir, Eudragit RL 100, Eudragit RS 100, Ethyl cellulose, Sustained release tablets.

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