Tuesday , 27 June 2017

Formulation Development and In-vitro Evaluation of Bosentan Gastroretentive Drug Delivery System

Seelam Manasa*, Y. Krishna Reddy
Bomma Institute of Pharmacy, Allipuram, Khammam, Telangana

A B S T R A C T
The present investigation of the development of floating tablets are used in the treatment of high blood pressure in the lungs (pulmonary arterial hypertension). The Bosentan floating tablets were prepared by direct compression method. The evaluation of Precompression Blend Flow Properties of the granules of angle of repose shows the F1 to F9 20.60 θ to 29.50θ, Bulk density shows the F1 to F9 value was found to be 0.43 g/cc to 0.45 g/cc, compressibility index shows the F1 to F9 value was found to be 11.7 % to 15.3 %. The prepared Bosentan floating tablets such as thickness, hardness, weight variation, friability. The optimized formulation F7 contains the average thickness of 3.05mm, average hardness of 7.1 kg/cm2, friability of 0.12%, the buoyancy studies of the bosentan floating tablets show 5 mints to 13 mints & The total floating time of tablets 8 to more than 12 hours. The swelling index of floating tablet 124 mins. The In vitro dissolution studies of floaing tablets of best formulation F7 shows 99% Drug release bosentan floating tablets within 12 hours. The best formulation F7 performs the Kinetic models like zero, first, higuchi, krosmeyer peppas.

Keywords: Gastro retentive floating tablets, Bosentan, buoyancy studies.

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