Wednesday , 20 September 2017

Formulation Design and In-vitro Characterization of Topical Drug Delivery System of Clotrimazole Gel

B. Saraswathi*, G. Manasa, Dr. T. Satyanarayana and K. Lalitha
Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India

A B S T R A C T
The present research was carried out to develop the topical Clotrimazole ethosomal gels. Even though the TDDS faces the problem of drug permeation because of the rigid stratum corneum, it can be overcome by the use of penetration enhancers such as ethanol. The size of the Gel can be reduced by sonication thereby improving the skin permeation properties of gel. By encapsulating Clotrimazole gel the frequency of dosing can be reduced as gel cause the delivery of drug for almost 10hrs. Since the overall drug administered is reduced, the adverse drug reactions of Clotrimazole such as dizziness, allergy, hypotension, etc can also be reduced.

Keywords: Clotrimazole, Ethosomal gels

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