Monday , 21 January 2019

Formulation and Optimization of Telmisatran Sustained Release Transdermal Films

Tadakapally Ramchandar1*, Jimidi Bhaskar2, V.L. Narasaiah3, Devara Raj Kumar 4
1.4Department of Pharmaceutics, Mother Teresa college of Pharmacy, Ghatkesar, Hyderabad, Telangana, India.
2Department of Bio-Technology, Avanthi Institute of Pharmaceutical Sciences, Gunthapally, Near Ramoji Film city, Hyderabad, Telangana, India.
3Dept. of Pharmaceutics, Dr Samuel George Institute of Pharmaceutical Sciences, Markapur, Prakasam, A.P, India.

The present investigation was aimed to develop sustained release transdermal therapeutic system containing Telmisartan with different ratios of Eudragit RS 100 and polyvinyl alcohol (PVA) by solvent-evaporation technique. Delivery of the drug via skin would provide a useful alternative to oral delivery, which has undesirable side effects, such as upper respiratory infections and disturbance of normal gut flora. The physicochemical compatibility of the drug and the polymers was by Fourier Transform Infra-Red (FTIR) and DSC. The results suggested no physicochemical incompatibility between the drug and the polymers. Blank films were prepared and evaluated characteristics like smoothness and flexible. Further drug loaded films were prepared and evaluated for thickness, tensile strength, weight uniformity, drug content, moisture content, moisture uptake, swelling index, water vapor transmission and in-vitro-drug permeation study. The results followed zero order kinetics and the mechanism of release was diffusion controlled release and further it was found to be linear with korsemeyer-peppas equation and confirmed that diffusion follows Non-Fickian transport. Based on the in-vitro dug permeation studies using rat skin, F6 formulation (1:5 ratios of PVA and Eudragit RS-100) produce 93% drug release in 7 hours.
Keywords: Telmisartan, Transdermal drug delivery, penetration enhancers, Eudragit RS-100, PVA, Solvent evaporation method

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