Monday , 24 February 2020

Formulation and In-vitro Evaluation of Terfenadine Non-Effervescent Floating Tablets

T. Anil kumar1, Kamera Kishore2, Dr. Gampa Vijay Kumar3*
1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

A  B  S  T  R A C T
The objective of the present work is preparing non effervescent floating tablets. The gas generating agent accrual was added in different concentrations with varying amount of retardation polymers. Chitosan xanthan gum karaya gum was used as retarding polymers. The formulation blend was evaluated for various physicochemical properties and all the parameters were found to be within limits. The formulations F1-F9 were formulated and evaluated for various quality control parameters. All the formulations were passed the tests and the results were within limits. From the dissolution data it was evident that formulation F8 was found to be best with the maximum % drug release of 98.41% and lag time of 12 hours.
Keywords: Terfenadine, Chitosan, xanthan gum karaya gum & Floating tablets.

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